Guayusa(Ilex guayusa) is an Amazonian plant that has been used for centuries by indigenous people in Ecuador to promote alertness and focus during hunts and rituals.
In this article you will discover its composition, proven and potential benefits, risks and tips for responsible use.
What exactly is Guayusa?
Guayusa belongs to the same family as Yerba Maté. The leaves are dried, lightly roasted and used as an herbal tea. Due to the combination of caffeine, theobromine and antioxidants, Guayusa provides energy without the sudden “crash” that coffee often causes.
The composition of Guayusa
The leaves contain various bioactive compounds that affect energy, concentration and cell protection:
- Caffeine – stimulates the central nervous system and increases alertness.
- Theobromine – known from cocoa, provides a calmer and longer-lasting feeling of energy.
- Antioxidants – such as polyphenols and catechins that neutralize free radicals.
- Amino acids – possibly L-theanine, which modulates the effect of caffeine and promotes rest.
Scientifically researched benefits of Guayusa
Energy and concentration
The natural caffeine in Guayusa may help you stay focused longer. A
Antioxidant effect
Guayusa contains many antioxidants that can protect cells from oxidative stress. Although animal studies show positive results, there is still limited clinical evidence in humans. Nevertheless, some animal studies suggest a positive effect on overall vitality.
Metabolism and blood sugar
There is preliminary evidence that Guayusa may slightly stimulate fat burning and keep blood sugar stable. However, these effects have not yet been scientifically proven in humans and require more research.
Mood and mental clarity
Many users report a slight improvement in mood and mental clarity. This effect is probably caused by the balance between stimulating (caffeine) and relaxing (theobromine, amino acids) constituents.
Safety and potential risks
Guayusa appears safe with traditional use and moderate dosage. Toxicological studies show no genotoxic effects. However, note the following points:
- Excessive use can cause restlessness, insomnia or palpitations.
- The tannins in Guayusa can reduce iron absorption.
- With medication use (such as blood pressure medications or antidepressants), interactions may occur.
Use is not recommended during pregnancy, lactation, in children or in sensitive health conditions without consulting a physician.
How do you use Guayusa?
Guayusa tea brewing
Use 2 grams of dried leaves per cup. Soak for 5-7 minutes in hot (but not boiling) water for mild flavor and gradual energy. Optionally combine with lemongrass or mint for a fresh taste.
Guayusa extracts and tinctures
Concentrated extracts also exist, often in capsules or tinctures . These are more potent but less researched. Use only according to the recommended dosage and, if in doubt, consult a professional.
Guayusa versus coffee and yerba maté
Compared to coffee, Guayusa contains less caffeine per cup, but a broader spectrum of supporting substances such as theobromine and antioxidants. This provides a more even energy level. It is most similar in taste and effect to Yerba Maté, but is often softer in flavor.
In conclusion
Guayusa is an interesting natural alternative to coffee and energy drinks. It provides a gentle, long-lasting energy boost without extreme peaks or valleys. Although scientific evidence is still limited, both traditional knowledge and early studies point to potential benefits for energy, focus and antioxidant protection. Guayusa seems particularly suitable for healthy adults seeking a mild, natural source of energy and focus without the drawbacks of coffee or synthetic stimulants.
- Guayusa gives mild energy without caffeine crash
- Contains antioxidants and theobromine
- Still limited research in humans
- Use in moderation and when in doubt, consult a physician
Scientific sources
- One study showed that Guayusa extract increased cognitive performance and perceived energy ( Wesnes et al., 2024 ).
- In cell studies, Guayusa was found to have strong antioxidant and anti-inflammatory effects(Chandrasekara et al., 2018).
- Guayusa contains chlorogenic acid, quercetin and carotenoids, among others ( Delgado et al., 2017 ).
- Under normal use, Guayusa is safe, comparable to other teas ( Glatfelter et al., 2019 ).
- Toxicological studies found no adverse effects(Hayes et al., 2016).
Disclaimer
Note: This information is for educational purposes only and does not replace medical advice. The efficacy of Guayusa has not yet been sufficiently clinically substantiated. Consult a physician or nutritionist before using Guayusa, especially with health conditions or medication use.

